Personally, I use Comodo for my Firewall (free) though I've yet to test their Anti-Virus. Firefox 3 is the way forward (with "NoScript", IETab and AdBlock Plus the essentials to add-on)(free) and I use AVG 8 for my anti-virus. I use Comodo's BOClean to protect from Malware (who also do Website Verification)(free). I'd personally avoid Windows Defender having had a number of issues with it. Instead, for occasional scanning I'd recommend Lavasoft's AdAware (free).
I've yet to get a virus on my machine in 3 years and I've even checked it with other on-line scanners.
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